How inflammation could age you with Prof. Philip Calder

Inflammation is a complicated topic. Short-term inflammation plays an essential role in fighting infections and healing injuries. But too much inflammation can be a catalyst for chronic ailments, like heart disease, type 2 diabetes, autoimmune disorders, rheumatoid arthritis, and obesity.

What we eat can influence our inflammatory responses and contribute to chronic, low-grade inflammation.

In today’s episode, Prof. Philip Calder helps us understand the science behind inflammation, how it impacts our health and what food has to do with it.

Philip is head of the School of Human Development and Health, as well as a Professor of Nutritional Immunology, in the Faculty of Medicine at the University of Southampton. He’s also an internationally recognised researcher on the metabolism and functionality of fatty acids. His work focuses on the roles of omega-3 fatty acids and the influence of diet and nutrients on immune and inflammatory responses. 

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Timecodes

00:00 Introduction

01:20 Quickfire questions

02:55 The role of inflammation in immunity

05:30 Chronic inflammation and disease

08:30 How to measure inflammation

09:53 Low-grade inflammation and disease risk

12:30 What causes blood vessel inflammation?

15:23 What creates the narrowing of blood vessels?

17:20 How inflammation can cause blood clots, heart attacks and strokes

19:15 Inflammation and aging

21:40 Inflammation and lifestyle factors

25:07 Obesity and inflammation

28:45 Muscle loss and inflammation (sarcopenia)

30:52 The impact of meals, sugar and fats on inflammation

33:35 How diet could reduce inflammation

34:42 Why we all respond to food differently

38:42 Dietary choices to manage inflammation

40:00 What are omega-3s?

41:17 Anti-inflammatory foods

43:40 Health benefits of omega-3 fatty acids

45:55 Challenges with farmed salmon

📚 Books from our ZOE Scientists:

Mentioned in today's episode:

Omega-3 polyunsaturated fatty acids and inflammatory processes: Nutrition or pharmacology? in the British Journal of Clinical Pharmacology

Omega-6 fatty acids and inflammation in PLEFA

Omega-3 fatty acids and inflammatory processes in Nutrients 

Another relevant study:

Health relevance of the modification of low-grade inflammation in ageing and the role of nutrition in Ageing Research Reviews

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Episode transcripts are available here.